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Will off-target gene editing in CRISPR therapeutics ever be completely eliminated, or will transient RNA targeting replace permanent DNA modification?
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Latest Science News
In Vivo CRISPR Lipid Nanoparticle Delivery Enters Clinical Trials for Transthyretin Amyloidosis
Intravascular administration of Cas9 mRNA and sgRNA encapsulated in LNPs successfully achieved targeted gene knockout in liver tissue with durable serum TTR reduction.
AlphaFold 3 Accelerates Molecular Docking & Protein-RNA Interaction Predictions
DeepMind's latest structural bio-ai architecture resolves complex nucleic acid-protein interfaces with unprecedented atomic accuracy.
Neoantigen-Targeted mRNA Cancer Vaccines Demonstrate Durable T-Cell Memory in Pancreatic Cancer
Personalized mRNA vaccines encoding patient-specific tumor neoantigens induced prolonged relapse-free survival in phase II trials.